ISGSB2026

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Programme

ISGSB 2026: The 22nd conference on International Study Group for Systems Biology · 7 Sep–11 Sep 2026 · Ljubljana

Oral session Plenary / keynote Poster session Award & ceremony Social Meeting Break & meal
Jump to day: Mon, 7 Sep Tue, 8 Sep Wed, 9 Sep Thu, 10 Sep Fri, 11 Sep
Time Main hall Auditorium Satellite Event YISGSB ELIXIR community hybrid meeting
NIB
Monday, 7 September 2026
10:00–16:00
YISGSB
12:30–14:00 Lunch
17:30–18:30
18:30–21:00
Tuesday, 8 September 2026
08:30–10:00
10:00–10:30 Coffee break
10:30–12:30
12:30–14:00 Lunch
14:00–15:30
15:30–15:50
16:00–18:00
Poster session and beer tasting
Wednesday, 9 September 2026
08:30–10:00
10:00–10:30 Coffee break
10:30–12:30
12:30–14:00 Lunch
14:00–15:30
15:30–15:50
16:00–18:00
Poster session and wine tasting
Thursday, 10 September 2026
08:30–10:00
10:00–10:30 Coffee break
10:30–12:30
12:30–14:00 Lunch
13:30–14:30
13:30–15:30
15:00–18:00
16:00–18:00
19:30–22:30
Friday, 11 September 2026
08:30–10:00
08:30–10:00
10:00–10:30 Coffee break
10:30–12:30
10:30–12:30
12:30–13:30 Lunch

Abstracts

Jump to day: Mon, 7 Sep Tue, 8 Sep Wed, 9 Sep Thu, 10 Sep Fri, 11 Sep
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Monday, 7 September 2026
Ice breaking activity
Mon, 7 Sep 10:00–16:00 · YISGSB

No abstracts in this session.

Science Communication Workshop
Mon, 7 Sep 10:00–16:00 · YISGSB

No abstracts in this session.

PowerPoint Karaoke
Mon, 7 Sep 10:00–16:00 · YISGSB

No abstracts in this session.

Rožnik walk
Mon, 7 Sep 10:00–16:00 · YISGSB

No abstracts in this session.

Registration
Mon, 7 Sep 17:30–18:30 · Auditorium

No abstracts in this session.

Welcome reception
Mon, 7 Sep 18:30–21:00 · Auditorium

No abstracts in this session.

Tuesday, 8 September 2026
Theory and dynamics of metabolic modelling (Part 1) Ines Heiland
Tue, 8 Sep 08:30–10:00 · Main hall
  • 08:30–08:50 O1 Functional consequences of the autocatalytic structure of glycolysis: energy-status homeostasis and flux maximization
    Luis A. Salinas-Te, Frank Bruggeman, Jacky Snoep, Bas Teusink
  • 08:50–09:10 O2 Metabolomics and fluxomics in ex vivo precision-cut liver slices of Glycogen Storage Disease type I
    Esther Homan, Martijn Rutten, Kishore Krishnamurthy, Candelas Gross Valle, Albert Gerding, Miriam Makkinje, Pim de Blaauw, Trijnie Bos, Peter Olinga, Bart van de Sluis, Terry Derks, Justina Wolters, Maaike Oosterveer, Rebecca Heiner-Fokkema, Barbara Bakker
  • 09:10–09:30 O3 The role of fatty acid oxidation during combined fasting and acute cold stress: Metabolic reprogramming of glucose and lipid metabolism
    Anette Haak, Ligia Akemi Kiyuna, Anne-Claire M. F. Martines, Wenxuan Zhang, Albert Gerding, Miriam Makkinje, Niels Kloosterhuis, Marieke Smit, Rick Havinga, Maaike Goris, Marcel de Vries, Mirjam H. Koster, Laura Bongiovanni, Alain de Bruin, Rob H. Henning, Rainer Bischoff, Terry Derks, Justina Wolters, Maaike H. Oosterveer, Dirk-Jan Reijngoud, Barbara Bakker
  • 09:30–09:50 O4 Exploring new venues in single-molecule transcriptomics with the SQANTIverse
    Ana Victoria Conesa Cegarra
Mechanistic modelling meets multi-omics: Towards personalised and predictive systems biology Anu Raghunathan
Tue, 8 Sep 10:30–12:30 · Main hall
  • 10:30–10:50 O5 Expanding enzyme-constrained metabolic modelling to human systems: A Julia-based pipeline demonstrates high predictive power
    Hugues Escoffier, Thomas Sauter
  • 10:50–11:10 O6 Investigating P. falciparum metabolism by integrating quantitative biochemical analysis and Genome Scale Metabolic modelling
    Tasmin Summerton, Jacky Snoep, Dawie van Niekerk
  • 11:10–11:30 O7 Physiologically relevant Multi-Omics Flux Analysis Reveals Metabolic Mechanisms of drug-Induced Liver Toxicity
    Zita Soons, A. Zeynep Sayin, Lars Blank, Marco Oldiges, Henrik Cordes, Lars Kuepfer
  • 11:30–11:50 O8 Signal propagation on causal fish knowledge network for proliferation
    Miha Tome, Sven Lukas Mosimann, Barbara Jozef, Kristin Schirmer, Anže Županič
  • 11:50–12:10 O9 Mathematical Modelling of the Impact of Age and Sex Steroids on Female Blood Pressure Regulation
    Elena Katharina Heinze, Carolina Ramirez Mazo, Anagha Madhusudan Joshi-Michoel, Ines Heiland, Susanna Röblitz
  • 12:10–12:30 O10 Strategies for the use of Universal Differential Equations to advance Personalised Medicine.
    Shauna O'Donovan, Max de Rooij, Natal van Riel
Computational models for plant growth, stress, and interactions Anna Matuszyńska
Tue, 8 Sep 14:00–15:30 · Main hall
  • 14:00–14:20 O11 Investigating the principles of plant growth-defence trade-offs in biotic interactions using metabolic modelling
    Jan Zrimec, Sandra Correa, Maja Zagorščak, Carissa Bleker, Marko Petek, Katja Stare, Kristina Gruden, Zoran Nikoloski
  • 14:20–14:40 O12 Inference of growth and division kinetics in a population balance model of Chlamydomonas reinhardtii with Gaussian process regression
    Michiel Busschaert, Michael Schagerl, Christian Griebler, Florence Vermeire, Steffen Waldherr
  • 14:40–15:00 O13 A metabolic model of the leaf-associated bacterium Paraburkholderia dioscoreae links the ethylene precursor ACC to core carbon pathways
    Pablo Rolle, Steffen Waldherr
  • 15:00–15:20 O14 A systems-level framework for mapping plant heat-stress memory into dynamic regulatory state-space
    El Hadji Malick Cisse, Anna Matuszyńska
Poster Slam 1
Tue, 8 Sep 15:30–15:50 · Main hall

No abstracts in this session.

Poster session 1
Tue, 8 Sep 16:00–18:00 · Auditorium
  • P1 Predicting hepatotoxic metabolites in drug metabolism
    Hester Chapman, Linda Chiappalupi, Oliver Ebenhöh
  • P2 Oxygen-dependent restructuring of circadian sterol biosynthesis in HepG2 cells revealed by generalised CosinorPy modelling of LC/MS-MS time-series data
    Katarina Nahtigal, Ana Halužan Vasle, Tinkara Kreft, Cene Skubic, Miha Mraz, Miha Moškon, Leja Dolenc Grošelj, Damjana Rozman
  • P3 Investigating the Reversibility of Rubisco’s Catalytic Mechanism and Its Implications for Carbon Fixation Models
    Yuval Goobes, Itay Halevy
  • P4 Analysing energy dissipation partitoning in different environmental conditions with the help of a mechanistic model of proton-motive force
    Josha Ebeling, Anna Matuszyńska
  • P5 Explainable graph neural networks for condition-specific gene expression analysis and link prediction in Arabidopsis
    Klara Šuštar, Aleš Kert, Tomaž Curk, Carissa Bleker, Jan Zrimec
  • P6 Potatoes local Ca2+ signalling in space and time
    Sergej Praček, Katja Fink, Carissa Bleker, Kristina Gruden, Anže Županič
  • P7 Bioelements: A tool to investigate biological phenomena in 2D
    Tim Nies, Marvin van Aalst
  • P8 Spatial transcriptomics analysis of complex skeletal muscle architecture
    Irma Zeljković, Simon Horvat, Špela Simoneta, Denis Korady, Tanja Kunej, Uršula Prosenc Zmrzljak, Miha Moškon, Nejc Umek
  • P9 Cellular Economics of Exchanged Metabolites Alter Ratios of Microbial Trading Partners in Predictable Manner
    Martina Du, Ross Carlson
    Pdf-of-the-poster-not-required Pdf-of-the-slides-for-the-interactive-poster-session-not-required
  • P10 Towards a Reproducible Thermodynamic Model of E. coli Gene Regulatory Network for the In-Silico Design of Unconventional Computing Platforms
    Ana Halužan Vasle, Miha Moškon
  • P11 A multi-meta-omics study of microbial metabolic potential and its manifestations in marine microbial communities
    Marcel Blaha, Julian Breinich, Yichi Zhang, Pranas Grigaitis
Wednesday, 9 September 2026
Metabolic modelling and multi-omics approaches in cancer research Miha Moškon
Wed, 9 Sep 08:30–10:00 · Main hall
  • 08:30–08:50 O15 Constraints-based metabolic modelling identifies ME2–ME3 synthetic lethality in temozolomide-resistant glioblastoma
    Anu Raghunathan, Madhuri Belekar, Vijendra Kavatalkar
  • 08:50–09:10 O16 Analysing tumour heterogeneity using scRNA-seq data and genome-scale metabolic models
    Ida Zeljković, Klara Kolenc, Ana Halužan Vasle, Miha Moškon
  • 09:10–09:30 O17 Integrated Multi-Omics and Flux Analysis Reveal Cell-State–Dependent Metabolic Responses to Dichloroacetate in Melanoma
    Mingjia Zhang, Bernard Evers, Miriam Makkinje, Albert Gerding, Karen van Eunen, Mathilde Jalving, Dirk-Jan Reijngoud, Barbara Bakker
    Presentation-slides
  • 09:30–09:50 O18 Transcriptome-driven constraint-based modelling reveals metabolic targets for ovarian cancer
    Kate Meeson, Jean-Marc Schwartz
Refining and engineering the predictive blueprint of microbial cells Anže Županič
Wed, 9 Sep 10:30–12:30 · Main hall
  • 10:30–10:50 O19 Cell Geometry and Membrane Protein Crowding Constrain Escherichia coli Growth Rate, Overflow Metabolism, Respiration, and Maintenance Energy.
    Ross Carlson, Campbell Putnam, Ashley Beck
  • 10:50–11:10 O20 Thermodynamics of Microbial Growth under nutrient limitation
    Oliver Ebenhöh
  • 11:10–11:30 O21 Are Computational Predictions of Essential Genes as precise as Experiments?
    Pareena Verma, Mark Poolman
  • 11:30–11:50 O22 Generation of metabolomic-informed models of metabolism in complex microbial communities
    Coralie Muller, Sylvain Prigent, Clémence Frioux
  • 11:50–12:10 O23 Metabolic modeling of fungal pathogens – Gains and limitations
    Sascha Schäuble, Mohammad Mirhakkak, Wassili Dimitriew, Stefan Schuster, Gianni Panagiotou
  • 12:10–12:30 O24 The art of phenotype design: unlocking StrainDesign for complex substrate utilization
    Maaike Remeijer, Ingrid Persitz, Vasilis Flouris, Frank Bruggeman
Theory and dynamics of metabolic modelling (Part 2) Johann Rohwer
Wed, 9 Sep 14:00–15:30 · Main hall
  • 14:00–14:20 O25 Use of non-autonomous differential equations in modelling metabolic processes
    Stefan Schuster, Suman Chakraborty
  • 14:20–14:40 O26 The dynamic world of metabolic cofactors
    Anna Liedl, Lena Elise Høyland, Mathias Ziegler, Ines Heiland
  • 14:40–15:00 O27 From large networks to large dynamic models: the steps and missteps of going big
    Radoslav Atanasoski, Carissa Bleker, Sergej Praček, Maja Zagorščak, Tomaž Curk, Kristina Gruden, Anže Županič
  • 15:00–15:20 O28 Model Refinement of Partially Specified Boolean Networks Using Phenotype Control
    David Safranek, Samuel Pastva, Eva Smijakova
Poster Slam 2
Wed, 9 Sep 15:30–15:50 · Main hall

No abstracts in this session.

Poster session 2
Wed, 9 Sep 16:00–18:00 · Auditorium
  • P12 NAViFluX: A Visualization-Centric Workbench for Interactive Analysis, Refinement, and Design of Genome-Scale Metabolic Networks
    Manjunatha B K, P S Harish, Abhishek Subramanian
  • P13 Thermodynamic energy constraints shape enzyme sequence and active-site geometry: evidence from methanogenic archaea across the energetic spectrum of life
    Tamir Yerushalmi, Itay Halevy
  • P14 Modular response analysis reveals distributed control of insulin sensitivity in C2C12 skeletal muscle cells.
    Klarissa Shaw, Dawie van Niekerk, Jacky Snoep
  • P15 Reconstruction of context-specific genome-scale metabolic models of mammalian cells: development of a robust protocol
    Tadeja Režen, Andrew Walakira, Cene Skubic, Miha Mraz, Damjana Rozman, Miha Moškon
  • P16 pyPGLM, a toolbox for the fast contextualization of logical networks
    Sébastien De Landtsheer, Salma Bayoumi, Thomas Sauter
  • P17 A digital tomato: modelling resource allocation in young growing fruit
    Chloé Ladreyt, Sophie Colombié, Anne Goelzer
  • P18 Development of an interactive web application for constraint based modelling
    Zuhtu Tutar, Saad Rasool, Kate Meeson, Jean-Marc Schwartz
  • P19 Subtype-Specific Gene Expression and Proliferation Dynamics in 2D and 3D High-Grade Serous Ovarian Cancer Cell Cultures
    Vesna Kokondoska Grgič, Renata Pavlič, Aleksandar Janev, Mateja Erdani Kreft, Katja Kološa, Lana Černigoj, Jurica Levatić, Sašo Džeroski, Maša Sinreih, Tea Lanišnik Rižner, Ivana Jovčevska
  • P20 Investigating metabolic reprogramming in pancreatic ductal adenocarcinoma using genome-scale metabolic modelling
    Filip Petrovič, Ana Halužan Vasle, Juan Sebastian Solano Gutierrez, Klementina Fon Tacer, Miha Moškon
  • P21 The role of fungal LysM effectors in plant immunity suppression and microbiota manipulation
    Flora Schlüter, Oliver Ebenhöh, Bart Thomma
  • P22 ANCHORS - Attention-based Neural Computation and Hybrid model Optimization for Reconstruction of Complex Dynamic Biological Systems
    Žiga Pušnik
  • P23 Metabolic-isotopic model of sulfite reduction: Environmental and evolutionary implications
    Maayan Kaneti, Itay Halevy
  • P24 Integration of omics data for response prediction to neoadjuvant treatment in resectable Non-Small Cell Lung Cancer
    Margarita Lusnicenko, Janis Kurlovics, Rui Tavares, Egils Stalidzans
  • P25 TRIM-Flux: Integrating Metabolic Flux into Multimodal VAEs for Predicting T-cell State Transitions in Cancer Immunotherapy
    Aljaž Kos, Ana Halužan Vasle, Miha Moškon
  • P26 Using the ReStoRunT idea to document provenance in transformation of large, complex Excel workbooks
    Wolfgang Müller, Maja Rey, Anne Elin Heggland, Alper Daggez
Thursday, 10 September 2026
Metabolic cross-feeding and inter-species dynamics Frank Bruggeman
Thu, 10 Sep 08:30–10:00 · Main hall
  • 08:30–08:50 O29 Metabolic games in an autotroph-heterotroph consortium: eco-evolutionary analysis of cooperative, private and cheater exoenzyme strategies
    Tanvir Hassan, Shalu Dwivedi, Stefan Schuster, Anna Matuszyńska
  • 08:50–09:10 O30 Fermentation revisited: facultative anaerobes and the rate-yield trade-off in the gut microbiome
    Johannes Zimmermann
  • 09:10–09:30 O31 Butyrate production is shaped by microbial interactions in an infant synthetic community
    Coen Berns, Shijia Li, Yangwei Shan, Jianbo Zhang, Stanley Brul, Meike Wortel
  • 09:30–09:50 O32 Optimizing the resource allocation between biochemical defence and counter-counter defence in pathogenic and trophic interactions. Steady-state analysis
    Lukas Korn, Stefan Schuster
Bridging omics and metabolic models John Hancock
Thu, 10 Sep 10:30–12:30 · Main hall
  • 10:30–10:50 O33 COBRA-k: a novel framework bridging constraint-based and kinetic metabolic modeling
    Steffen Klamt, Pavlos Stephanos Bekiaris
  • 10:50–11:10 O34 ThermoDB – Metabolic Potentials Under User-Defined Conditions
    Johann Rohwer, Peter Halling, Carsten Kettner, Hans Westerhoff
  • 11:10–11:30 O35 From RNA-Seq to Mechanistic Insights: A Unified Pipeline for Context-Specific Metabolic Model Analysis
    Vanille Lejal, Leonie Thomas, Maria Pires Pacheco, Thomas Sauter
  • 11:30–11:50 O36 scFASTCORMICS 2.0: Fast and Scalable Context-Specific Metabolic Modeling from Single-Cell RNA-seq Data of the Tumor Microenvironment
    Evelyn Gonzalez, Maria Pires Pacheco, Thomas Sauter
  • 11:50–12:10 O37 Functional tracer proteo-metabolomics: a toolbox to study cellular metabolism and protein modification dynamics
    Marcel Kwiatkowski, Tobias Kipura, Alina Hohenegg, Nick Sartison, Nora Mehwald, Ines Heiland, Anna-Sophia Egger-Hörschinger, Madlen Hotze
  • 12:10–12:30 O38 Developing Approaches for Knowledge-Driven Protein 3D Structure Prediction: Next Steps Beyond AI
    Tareq Hameduh, Andrew D. Miller, Zbynek Heger, Yazan Haddad
Session 1 (ELIXIR)
Thu, 10 Sep 13:30–15:30 · NIB

No abstracts in this session.

ISGSB Board meeting
Thu, 10 Sep 13:30–14:30 · Main hall

No abstracts in this session.

Excursion (historic city tour or hike)
Thu, 10 Sep 15:00–18:00 · Satellite Event

No abstracts in this session.

Session 2 (ELIXIR)
Thu, 10 Sep 16:00–18:00 · NIB

No abstracts in this session.

Conference dinner (Pivnica Union)
Thu, 10 Sep 19:30–22:30 · Satellite Event

No abstracts in this session.

Friday, 11 September 2026
Systems biology communities & services Carissa Bleker
Fri, 11 Sep 08:30–10:00 · Main hall
  • 08:30–08:50 O39 The ELIXIR Systems Biology Community and Advancing FAIR and Trustworthy Systems Biology: From Principles to AI-Enhanced Practice
    John Hancock, Mihail Anton, Irina Balaur, Frank Bergmann, Carissa Bleker, Thomas Collin, Oscar Dias, Elena Domínguez-Romero, Chris Evelo, Martina Kutmon, Vitor Martins dos Santos, Anna Matuszyńska, Sebastien Moretti, Anna Niarakis, Marek Ostaszewski, Miguel Rocha, David Safranek, Rahuman Sheriff, Maria Suarez-Diez, Dagmar Waltemath, Ulrike Wittig, Jan Zrimec, Anže Županič
  • 08:50–09:10 O40 Improving Accessibility, Curation and Reusability of Enzyme Kinetic Data in SABIO-RK
    Ulrike Wittig, Maja Rey, Xiaoming Hu, Wolfgang Müller
  • 09:10–09:30 O41 Interfacing systems biology diagrams and Large Language Models with the MINERVA Platform
    Marek Ostaszewski, Venkata Satagopam, Reinhard Schneider
Session 4 (ELIXIR)
Fri, 11 Sep 10:30–12:30 · NIB

No abstracts in this session.

Theory and dynamics of metabolic modelling (Part 3) Stefan Schuster
Fri, 11 Sep 10:30–12:30 · Main hall
  • 10:30–10:50 O42 Oscillatory wave propagation in yeast and β-cell populations
    Jacky Snoep, Morne van Wyk, Dennis Botman, Raagini Biswas, Alison Munsamy, Klarissa Shaw, Caroline Adiels, Dawie van Niekerk
  • 10:50–11:10 O43 Quantitative Phasor Analysis of Biological Oscillators
    Dawie van Niekerk, Joshua Kilian, Franco du Preez, Jacky Snoep
  • 11:10–11:30 O44 Age-based approach to characterize the dynamics of cellular processes
    Elad Noor, Evgeny Onischenko
    Presentation-slides
  • 11:30–11:50 O45 Clostridial acidogenesis product profiles are discontinuous: a thermodynamic hypothesis
    Christoff Odendaal, Marit Verheijen, Rebeca Gonzalez-Cabaleiro
  • 11:50–12:10 O46 Making sense of time series with universal differential equations
    Marvin van Aalst
  • 12:10–12:30 O47 FASTERCC: Accelerating Flux Consistency Testing and Context-Specific Reconstruction for Large-Scale Metabolic Network Models
    Evelyn Gonzalez, Maria Pires Pacheco, Thomas Sauter
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